Evolutional insights on uncharacterized SARS coronavirus genes
Identifieur interne : 001668 ( Pmc/Checkpoint ); précédent : 001667; suivant : 001669Evolutional insights on uncharacterized SARS coronavirus genes
Auteurs : Alex Inberg ; Michal LinialSource :
- Febs Letters [ 0014-5793 ] ; 2004.
Abstract
The complete genome of the severe acute respiratory syndrome coronavirus (SARS‐CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC‐ORFs). Here, we try to provide a relational insight on those UC‐ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC‐ORFs exhibit considerable similarity with other SARS‐CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS‐CoV.
Url:
DOI: 10.1016/j.febslet.2004.09.076
PubMed: 15527778
PubMed Central: 7125658
Affiliations:
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<front><journal-meta><journal-id journal-id-type="nlm-ta">FEBS Lett</journal-id><journal-id journal-id-type="iso-abbrev">FEBS Lett</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)1873-3468</journal-id><journal-id journal-id-type="publisher-id">FEB2</journal-id><journal-title-group><journal-title>Febs Letters</journal-title></journal-title-group><issn pub-type="ppub">0014-5793</issn><issn pub-type="epub">1873-3468</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15527778</article-id><article-id pub-id-type="pmc">7125658</article-id><article-id pub-id-type="doi">10.1016/j.febslet.2004.09.076</article-id><article-id pub-id-type="publisher-id">FEB2S001457930401213X</article-id><article-categories><subj-group subj-group-type="overline"><subject>Short Communication</subject></subj-group><subj-group subj-group-type="heading"><subject>Short Communications</subject></subj-group></article-categories><title-group><article-title>Evolutional insights on uncharacterized SARS coronavirus genes</article-title></title-group><contrib-group><contrib id="feb2s001457930401213x-cr-0001" contrib-type="author"><name><surname>Inberg</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="feb2s001457930401213x-aff-0001"><sup>1</sup></xref></contrib><contrib id="feb2s001457930401213x-cr-0002" contrib-type="author" corresp="yes"><name><surname>Linial</surname><given-names>Michal</given-names></name><xref ref-type="aff" rid="feb2s001457930401213x-aff-0001"><sup>1</sup></xref><address><email>michall@cc.huji.ac.il</email></address></contrib></contrib-group><aff id="feb2s001457930401213x-aff-0001"><label><sup>1</sup></label>Dept of Biological Chemistry, Life Science Institute, The Hebrew University, Jerusalem, 91904 Israel</aff><author-notes><corresp id="correspondenceTo"><label>*</label>Corresponding author. Fax: +97-226-586-448</corresp></author-notes><pub-date pub-type="ppub"><day>05</day><month>11</month><year>2004</year></pub-date><pub-date pub-type="epub"><day>13</day><month>10</month><year>2004</year></pub-date><volume>577</volume><issue>1-2</issue><issue-id pub-id-type="doi">10.1002/feb2.2004.577.issue-1-2</issue-id><fpage>159</fpage><lpage>164</lpage><history><date date-type="received"><day>09</day><month>6</month><year>2004</year></date><date date-type="rev-recd"><day>30</day><month>9</month><year>2004</year></date><date date-type="accepted"><day>30</day><month>9</month><year>2004</year></date></history><permissions><pmc-comment> © 2015 Federation of European Biochemical Societies </pmc-comment>
<copyright-statement content-type="article-copyright">FEBS Letters 577 (2004) 1873-3468 © 2015 Federation of European Biochemical Societies</copyright-statement><license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="file:FEB2-577-159.pdf"></self-uri><abstract><p>The complete genome of the severe acute respiratory syndrome coronavirus (SARS‐CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC‐ORFs). Here, we try to provide a relational insight on those UC‐ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC‐ORFs exhibit considerable similarity with other SARS‐CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS‐CoV.</p></abstract><kwd-group><kwd id="feb2s001457930401213x-kwd-0001">SARS, severe acute respiratory syndrome</kwd><kwd id="feb2s001457930401213x-kwd-0002">ORF, open reading frame</kwd><kwd id="feb2s001457930401213x-kwd-0003">UC-ORF, uncharacterized open reading frame</kwd><kwd id="feb2s001457930401213x-kwd-0004">CoV, coronavirus</kwd><kwd id="feb2s001457930401213x-kwd-0005">HIV, human immunodeficiency virus</kwd><kwd id="feb2s001457930401213x-kwd-0006">Viral evolution</kwd><kwd id="feb2s001457930401213x-kwd-0007">Sequence homology</kwd><kwd id="feb2s001457930401213x-kwd-0008">Remote homolog</kwd><kwd id="feb2s001457930401213x-kwd-0009">Hypothetical protein</kwd><kwd id="feb2s001457930401213x-kwd-0010">Coronavirus</kwd><kwd id="feb2s001457930401213x-kwd-0011">Proteome</kwd></kwd-group><counts><page-count count="6"></page-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>November 05, 2004</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:15.04.2020</meta-value></custom-meta></custom-meta-group></article-meta><notes><p content-type="self-citation"><mixed-citation publication-type="journal" id="feb2s001457930401213x-cit-0000"><string-name><surname>Inberg</surname><given-names>Alex</given-names></string-name> and <string-name><surname>Linial</surname><given-names>Michal</given-names></string-name>(<year>2004</year>), <article-title>Evolutional insights on uncharacterized SARS coronavirus genes</article-title>, <source xml:lang="en">FEBS Letters</source>, <volume>577</volume>, doi: 10.1016/j.febslet.2004.09.076</mixed-citation></p></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Inberg, Alex" sort="Inberg, Alex" uniqKey="Inberg A" first="Alex" last="Inberg">Alex Inberg</name><name sortKey="Linial, Michal" sort="Linial, Michal" uniqKey="Linial M" first="Michal" last="Linial">Michal Linial</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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